- Title
- Derivation and representation of dose-volume response from large clinical trial data sets: an example from the RADAR prostate radiotherapy trial
- Creator
- Ebert, M. A.; Foo, K.; Denham, J. W.; Haworth, A.; Gulliford, S. L; Kearvall, R.; Kennedy, A.; Richardson, S.; Krawiec, M.; Stewart, N.; Joseph, D. J.
- Relation
- XVII International Conference on the Use of Computers in Radiation Therapy (ICCR 2013). Journal of Physics: Conference Series, Volume 489 (Melbourne 6-9 May, 2013)
- Publisher Link
- http://dx.doi.org/10.1088/1742-6596/489/1/012090
- Publisher
- Institute of Physics (IOP)
- Resource Type
- conference paper
- Date
- 2014
- Description
- Large multicentre radiotherapy trials incorporating assessment of multiple outcomes at multiple timepoints can generate extensive datasets. We have investigated graphical techniques for presentation of this data and the associated underlying dose-volume response information, necessary for guiding statistical analyses and translating outcomes to future patient treatments. A relational database was used to archive reviewed plan data for patients accrued to the TROG 03.04 RADAR trial. Viewing software was used to clean and enhance the data. Scripts were developed to export arbitrary dose-histogram data which was combined with clinical toxicity data with a median follow-up of 72 months. Graphical representations of dose-volume response developed include prevalence atlasing, univariate logistic regression and dose-volume-point odds ratios, and continuous cut-point derivation via ROC analysis. These representations indicate variable association of toxicities across structures and time-points.
- Subject
- radiotherapy; dose-volume data; clinical outcomes
- Identifier
- http://hdl.handle.net/1959.13/1301139
- Identifier
- uon:20231
- Identifier
- ISSN:1742-6588
- Rights
- Published under licence in Journal of Physics: Conference Series by IOP Publishing Ltd.
- Language
- eng
- Full Text
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